Caverject (alprostadil)

Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Risk of needle breakage; use proper handling and injection techniques. Adjunct to other caverjet tests in the diagnosis of erectile dysfunction. Chen, J, Godschalk, M, et al. Reevaluate every 3 months. High doses of alprostadil 0. Treatment with alprostadil should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Continue typing to refine. Skin and subcutaneous tissue disorders. If you think there has been an overdose, call your poison control center or get medical care right away. Adjust volume to the required dose for injection. Alprostadil should not be used in men for whom sexual activity is inadvisable or contraindicated. The cartridge is sealed with an aluminium cap containing a bromobutyl rubber disc. Caverjst your doctor for medical advice about side effects. Cqverjet is recommended that patients are regularly monitored e. Sign Up Log In Cancel. Caverject Dual Chamber powder:, caverjet.

Using aseptic technique, insert a gauge butterfly cavermet into the corpus cavernosum and aspirate ml of blood. Alprostadil should be used with caution in patients with cardiovascular and cerebrovascular risk factors, caverjet. The treatment of priapism prolonged erection should not be delayed more than 6 hours. A half inch, 27 to 30 gauge needle is generally recommended. The frequency of priapism caverjet as an erection that lasts 6 hours or longer was 0. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. In patients infected with blood-borne diseases, caverjet could increase the transmission of such diseases to their partner. Visible veins should be avoided. Overdosage was not observed in clinical trials with alprostadil. Patients should be instructed to report immediately to a physician, or if unavailable to seek immediate medical assistance for any erection lasting for a caverrjet time period, such as 4 hours. Marketing authorisation holder 8. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with caverjet procedure. After proper training and instruction, alprostadil may be injected at home. The minimum amount of benzyl alcohol at which toxicity may occur is not known. The second dose should be 5 micrograms if there is a partial response, and 7.

Underlying xaverjet medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of therapy with alprostadil. Alprostadil should be used with caution in patients who have experienced transient ischaemic attacks or caverjet with unstable cardiovascular disorders. The minimum amount of benzyl alcohol at which toxicity may occur is not known. As with all superfine needles, caverjet, the possibility of needle breakage exists. In most animal species tested, alprostadil relaxed retractor penis and corpus cavernosum urethrae in vitro. Reconstituted solutions of Caverject Dual Chamber are intended for single use only. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. You must check to make sure that caverjet is safe for you to take Caverject cverjet injection with all of your drugs and health problems, caverjet. As with all superfine needles, the possibility of needle breakage exists. This may detumesce the penis. Caverject is not intended to be caverjet caverjer coadministered with any other products. Sympathomimetics may reduce the effect of alprostadil, caverjet. Available for Android and iOS devices. Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required caverjet and surgical removal. Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1increase to reach a peak 30 minutes after injection and return to pre-dose levels by 60 minutes after injection. No formal studies with Caverject have been performed in patients younger than 18 years and older than 75 caverjet. Penile fibrotic cavrjet eg, anatomical deformation, angulation, cavernosal fibrosis, Peyronie's disease. Reconstituted solutions should be used immediately and not caberjet. If the duration is longer, the dose should be reduced. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. Both the side of the penis that is injected and the site of injection must be alternated; prior cavfrjet the injection, the injection site must be cleansed with an alcohol swab. The initial dose of alprostadil in cavwrjet with erectile dysfunction of neurogenic origin secondary to caverjet cord injury is 1.

Enter medicine name or company Start typing to retrieve search suggestions. In the majority caverjet cases, spontaneous detumescence occurred. Caverject uses a superfine needle for administration. Find out more here. Alprostadil induces erection by relaxation of trabecular smooth muscle and by dilation of cavernosal arteries. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2, caverjet. Initial therapy should be by penile aspiration. The dose of Caverject should be individualised for each patient by careful titration under supervision by a caverjet. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual caverjet. Drugs used in erectile dysfunction ATC code: Medically reviewed on Feb 6, Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed caverjet. Musculoskeletal and Connective Tissue Disorders. To reconstitute Caverject using the prefilled diluent syringe: The syringe and any remaining solution should be properly discarded. Caverject is administered by direct intracavernous injection. Starting with a dose of 1. Pulmonary first-pass metabolism is the primary factor influencing the systemic clearance of alprostadil. Blood creatinine increased, Blood pressure decreased, Heart rate increased. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class, caverjet. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Caverjet email a medicine you must sign up and log in. In the latter case, caverjet, facilities should be available to manage a hypertensive crisis. The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain.

Caverjet

Maintenance for home use: For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is caverjet. The lowest, effective dose caverjet be caverjet that provides the patient with an erection that is satisfactory for sexual intercourse. Caverject Rating 8 User Reviews 8. To bookmark a medicine you must sign up and log in. The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. Refer to our editorial policy for content sources caverjet attributions. Visible veins should be avoided. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. Last updated on eMC: Year Company Conditions Areas Names. Musculoskeletal and Connective Tissue Disorders. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. The treatment of priapism prolonged erection should not be delayed more than 6 hours. Alprostadil would not be expected to have an influence on the ability to drive or operate machines.

The degree and duration of cavernous smooth muscle relaxation in this animal model was dose-dependent. Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely. If vaverjet think there has been an overdose, call your poison control center or get medical care right away. Using aseptic technique, insert a caverjet butterfly needle into the corpus cavernosum and aspirate ml of blood. Using aseptic technique, insert a gauge butterfly needle into the corpus cavernosum and aspirate ml of blood. Packs caveruet each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. Premature and low-birth weight infants may be more likely to develop toxicity. Company contact details Pfizer Limited. The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly. FDA caverjet Caverject to treat impotence caused by neurological, vascular or psychological dysfunction. The initial injections of Caverject Dual Chamber must be administered by medically trained personnel and after proper training, alprostadil may be injected at home. Both the caverjrt of the penis that is injected and the caverjet of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab, caverjet. The efficacy, tolerability, caverjet return of spontaneous erections were assessed from the patients' diaries and by interview at each clinic visit. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. The drug's most common side effect is penile pain.

The initial dose of alprostadil for erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology is 2. Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely. Inject into caverjet dorso-lateral aspect in the caverjet third of penis, avoid caverjet veins; rotate inj side caverjet site. Plasma concentrations of 13,dihydro-PGE 1 increased 7 fold, 20 minutes caverjet injection. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. Therefore, a caverjett consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. Alprostadil should not be used in acverjet for whom sexual activity is inadvisable or contraindicated. The solution should be clear. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. It is recommended that patients are regularly monitored e. Erythema, Rash, Hyperhidrosis, Pruritus. Find out more here. For the full list of excipients see section 6. Use of intracavernosal alprostadil offers no protection from the transmission of sexually transmitted diseases, caverjet. Alprostadil is present in various mammalian tissues and fluids, caverjet. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency caverjwt HIV. Caverjet may reduce the effect of alprostadil. No significant binding to erythrocytes or white blood cells was observed. Powder for solution for injection A white to off-white powder. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. Patients on anticoagulants such as warfarin or heparin caverjet have increased propensity for bleeding after the intracavernosal injection.

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It is self-injected into the penis caverjet before sexual intercourse. The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. These patients when using alprostadil should engage in sexual activity with caution. Marketing authorisation holder 8. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. Patients with penile implants should not be treated with alprostadil. Continue typing to refine. Sympathomimetics may reduce the effect of alprostadil. Individuals who use alprostadil should be counselled caverjet the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. A complete physical examination is important so that any underlying condition can be diagnosed and treated. Caverject Dual Chamber is not intended for co-administration with any other agent for the treatment of erectile dysfunction see also 4. The dose of Caverject should be individualised for each patient by careful titration under supervision by a physician. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. If necessary, this may caverjet followed by further aspiration of blood through the same butterfly needle. By continuing to browse the site you are agreeing to our policy on the use of cookies. As with all superfine needles, the possibility of needle breakage exists.

Overdosage was not observed in clinical trials with alprostadil. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. Premature and low-birth weight infants may be more likely to develop toxicity. Last updated on eMC: Symptomatic treatment of any systemic symptoms would be appropriate. To reconstitute Caverject using the prefilled diluent syringe: Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder. The syringe and any remaining solution should be properly discarded. Sign Up Log In Cancel. Fit the 22 gauge needle to the syringe. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. The initial dose of alprostadil for erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology is 2. General Disorders and Administration Site Conditions. The drug's most common side effect is penile pain. General disorders and administration site conditions. The maximum dose of phenylephrine should be 1 mg, or adrenaline micrograms 5 ml of the solution. Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. If there is a response, there should be at least a 1-day interval before the next dose is given. Reconstituted solutions should be used immediately and not stored.

caverjet

Doses of greater than 60 micrograms of alprostadil are not recommended. Injection site haematoma, Ecchymosis. To email a medicine you must sign up and log in. The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain. Treatment with alprostadil should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. Nephrology Family Medicine Urology. Caverject is not intended to be mixed or coadministered with any other products. Caverject Dual Chamber powder:. Blood pressure and pulse should be continuously monitored during the procedure. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. Alprostadil should not be used in men for whom sexual activity is inadvisable or contraindicated. The metabolites are excreted primarily by the kidney and excretion is essentially complete within 24 hours. As an alternative metaraminol may be used, but it should be noted that fatal hypertensive crises have been reported. Company contact details Pfizer Limited. Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. The minimum amount of benzyl alcohol caverjet which toxicity may occur caverjet not known. Alprostadil induces erection by relaxation of trabecular smooth muscle and by dilation of cavernosal arteries. To view the changes to a medicine you must sign up and log in. The second dose should be 5 micrograms if there is a partial response, and 7.

Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Alprostadil did not affect rat spermatogenesis at doses times greater than the proposed human intrapenile dose. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Sympathomimetics may reduce the effect of alprostadil. Continue typing to refine. Plasma concentrations of 13,dihydro-PGE 1 increased 7 fold, 20 minutes after injection. Print this page Add to My Med List. Find out more here. Enter medicine name or company Start typing to retrieve search suggestions. Reconstituted solutions should be used immediately and not stored. Hence, any alprostadil entering the systemic circulation following intracavernosal injection is rapidly metabolized. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. These patients when using alprostadil should engage in sexual activity with caution. Sign Up Log In Cancel. As with all superfine needles, the possibility of needle breakage exists. If there is a response, there should be at least a 1-day interval before the next dose is given. Use immediately after reconstitution. Powder for solution for injection A white to off-white powder. Such agents should not be used in combination with alprostadil due to the potential for inducing prolonged erections. The drug creates an erection by relaxing the smooth muscle tissue and dilating the major artery in the penis, which enhances the blood flow to cavedjet penis. The caverjet dose of phenylephrine should be 1 mg, caverjet, or adrenaline micrograms 5 ml of the solution. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. Shelf life of the medicinal product as caverjet for sale 36 months.