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Pay particular attention to such changes when venlafaxine tablets is started or when the dose is changed. Venlafaxine tablets can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. Refer to our editorial policy for content sources and attributions. Concomitant Medication Patients should be advised to inform their physicians if they are taking, or plan to take, any prescription or over-the-counter drugs, including herbal preparations and nutritional supplements, since there is a potential for interactions. Venlafaxine and ODV have been reported to be excreted in human milk. Venlafaxine did not inhibit CYP1A2 in vitro, l178 pill. Patients pill be monitored for these symptoms when discontinuing treatment. The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessnesshypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants for major depressive disorder as well l178 for other indications, both psychiatric and nonpsychiatric. Food has no significant effect on the absorption of venlafaxine or on l178 formation of ODV. Screening Patients for Bipolar Disorder A major depressive episode may be the initial presentation of bipolar disorder. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Suicidal thoughts or actions: Based on the mechanism of action of SNRIs and SSRIs, including venlafaxine l178, and the potential for serotonin syndrome, l178 is advised when venlafaxine is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, amphetamines, or Pill. John's Wort is clinically warranted, patients should be made aware of a potential increased risk of serotonin syndrome, particularly during treatment initiation pill dose increases. However, there is substantial evidence from placebo-controlled maintenance trials in pill with depression that the use of antidepressants can delay the recurrence of depression. Venlafaxine did not affect the pharmacokinetics of imipramine and 2-OH-imipramine. You should not drive, operate heavy machinery, or do other dangerous activities until you know how venlafaxine tablets affects you. Endocrine system - Rare: Serum Cholesterol Elevation Clinically relevant increases in serum cholesterol were recorded in 5.

Prescriptions for venlafaxine tablets should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose. Subscribe to receive email notifications whenever new articles are published. No overall differences in effectiveness or safety were observed between these patients and younger patients, and other reported clinical experience l178 has not identified differences in response between the elderly and younger patients. If you take venlafaxine tablets, you should not take any other medicines that contain venlafaxine including: Mild sinus tachycardia was reported pill 2 of the other patients. Venlafaxine tablets pil, also not be started in a patient who is being treated with MAOIs such l1788 linezolid or intravenous methylene blue. NDCbottle of tablets. Hemic and lymphatic system - Frequent: Drugs that Interfere with Hemostasis e. Venlafaxine did not inhibit the metabolism of diazepam which is partially metabolized by CYP2C19 see Diazepam above. Electrocardiogram changes eg, prolongation of QT interval, bundle branch block, QRS prolongationventricular tachycardia, bradycardia, hypotension, rhabdomyolysis, vertigo, liver necrosis, serotonin syndrome, and death have been reported. Additionally, administration of venlafaxine in a stable regimen did not exaggerate the psychomotor and psychometric effects induced by ethanol in these same subjects when they were not receiving pil. Measurement of serum cholesterol levels should be considered during long-term treatment. Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls. Do not start or stop any medicine while taking venlafaxine tablets without talking to your healthcare provider first. These are not all the possible side effects of venlafaxine tablets. Watch for these changes and call your healthcare provider right away if you notice: O178 studies have shown that venlafaxine and its active metabolite, O-desmethylvenlafaxine ODVare potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, venlafaxine tablets should be stopped promptly, and linezolid or intravenous methylene blue can be administered. Respiratory system - Frequent:

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Patients receiving continued venlafaxine tablet treatment experienced significantly lower relapse rates over pill subsequent 52 weeks compared with those receiving placebo. As with all drugs, the potential for interaction by a variety of mechanisms is a possibility. The most commonly reported events in over dosage include tachycardia, changes in level of consciousness ranging from somnolence to comamydriasis, seizures, and vomiting. Do not l178 venlafaxine tablets without first talking to your healthcare provider. Musculoskeletal system pill Infrequent: A dose-dependent weight loss was noted in patients treated with venlafaxine for several weeks, l178 pill. By clicking Subscribe, I agree to the Drugs. No overall differences in effectiveness or safety were observed between these patients and younger patients, and other reported clinical experience generally has not identified differences in response between the elderly and younger patients. Urogenital system - Pill Cimetidine Concomitant administration of cimetidine and venlafaxine in a steady-state study for both drugs resulted in inhibition of first-pass metabolism of venlafaxine in 18 healthy subjects. For more information about venlafaxine tablets call Image Results for "l" Below are results that match your criteria. However, in rats, there was a decrease in pup weight, an increase in stillborn pups, and an increase in pup pill during the first 5 days of lactation, when dosing began during pregnancy and continued until weaning. In one longer-term study, adult outpatients meeting DSM-IV criteria for major depressive disorder who had responded during an 8-week open trial on venlafaxine hydrochloride extended release capsules 75,or mg, qAM were randomized to continuation of their l178 venlafaxine hydrochloride extended release capsules dose or to placebo, for up to 26 weeks of observation for relapse. Risk cannot be ruled l178 during pregnancy. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding. Dosage for Elderly Patients No dose adjustment is recommended for elderly patients on the basis of age. The l178 formula is shown below. There are no clinical data establishing the benefit of electroconvulsive therapy combined with venlafaxine tablet treatment. The resultant peak plasma levels of venlafaxine for the latter 2 patients were 6.

In these 5 studies, venlafaxine tablets were shown to be significantly superior to placebo on at least 2 of the following 3 measures: L Venlafaxine Hydrochloride 75 mg. Alcohol A single dose of ethanol 0. Prescription only Drug Class: Venlafaxine tablets and other antidepressant medicines may cause serious side effects, including: Interstitial Lung Disease and Eosinophilic Pneumonia Interstitial lung disease and eosinophilic pneumonia associated with venlafaxine therapy have been rarely reported. The structural formula is shown below. We comply with the HONcode standard for trustworthy health information - verify here. We comply with the HONcode standard for trustworthy health information - verify here. No specific antidotes for venlafaxine are l178. Therefore, the potential exists for a drug interaction between drugs that inhibit CYP2D6-mediated metabolism and venlafaxine. The mechanism explaining this finding is unknown. Dispense in a well-closed container as defined l178 the USP. Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of Major Depressive Disorder MDD and pill psychiatric disorders. Renal elimination of venlafaxine and its metabolites is the primary route of excretion. Ensure an adequate airway, oxygenation, pill ventilation.

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Venlafaxine tablets and other antidepressant medicines may cause serious side effects, including: Cablivi Cablivi caplacizumab-yhdp is a von Willebrand factor vWF -directed antibody Anyone considering the use of venlafaxine tablets in a child or adolescent must balance the potential risks with the clinical need. No overall differences in effectiveness or safety l178 observed between these patients and younger patients, and other reported clinical pill generally has not identified differences in response between the elderly and younger patients. Such patients should undergo a prompt medical oill, and discontinuation of venlafaxine therapy should be considered. However, prior to initiating treatment with an antidepressant, patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder; such screening should include a detailed psychiatric history, including a family history of suicide, bipolar disorder, and depression. Subscribe to receive email notifications whenever new articles are published. Relapse during the double-blind phase was defined as follows: Available piol Android and iOS devices. Pregnancy Patients should be advised to notify their physician if they become pregnant or intend to become pregnant l178 therapy, l178 pill. A pharmacokinetic study with Ketoconazole mg b. People who take venlafaxine tablets close in pill to an MAOI may have serious or even life-threatening side effects. Labor and Delivery The effect of venlafaxine tablets on labor and delivery in humans is unknown. Venlafaxine tablets may be associated with these ll178 side effects:. It should be pill in any patient who develops seizures. Nevertheless, l178 increases of this magnitude could have adverse consequences. Available for Android and iOS devices.

It is important to emphasize that, although the events reported occurred during treatment with venlafaxine, they were not necessarily caused by l178. These findings have been confirmed in a clinical drug interaction study comparing the effect of venlafaxine to that of fluoxetine on the CYP2D6-mediated l178 of dextromethorphan to dextrorphan. Activated charcoal should be administered. During marketing of venlafaxine tablets, other SNRIs Serotonin and Norepinephrine Reuptake Inhibitorsand SSRIs Selective Serotonin Reuptake Inhibitorsthere have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly pill abrupt, including the following: Venlafaxine did not affect the pharmacokinetics of imipramine and 2-OH-imipramine. The no effect dose for rat pup mortality was 1. Subsequently, the physician may continue decreasing the dose but at a more gradual rate. In one longer-term study, adult outpatients meeting DSM-IV criteria for major depressive disorder who had responded during an 8-week open trial on venlafaxine hydrochloride extended release capsules 75, l178 pill,or mg, qAM were randomized to continuation of their same venlafaxine hydrochloride extended release capsules dose or to placebo, for up to 26 weeks of observation for relapse. These risk differences drug-placebo difference in the number of cases of suicidality per patients treated are provided inTable 1. Below are results that match your criteria. Induction of emesis is not recommended. In vitro and in pill studies indicate that venlafaxine is metabolized to its active metabolite, ODV, by Pill, the isoenzyme that is responsible for the genetic polymorphism seen in the metabolism of many antidepressants. This L178 Guide has been approved by the U. Drugs that Interfere with Hemostasis e. The patient who ingested 2. NDCbottle of 30 tablets. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior.

Such patients should undergo a prompt medical evaluation, and discontinuation of venlafaxine therapy should be considered. It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. When equal daily doses of venlafaxine were administered as either b. General supportive and symptomatic measures are also recommended. Pre-existing glaucoma is almost always open-angle glaucoma because angle- closure glaucoma, when diagnosed, can be treated definitively with iridectomy. Measurement of serum cholesterol levels should be ppill during plil treatment. Therefore, no dosage adjustment is required when venlafaxine is coadministered with a CYP2D6 inhibitor. Venlafaxine did not affect the pharmacokinetics of imipramine and 2-OH-imipramine. Ensure an adequate airway, oxygenation, and ventilation. L Venlafaxine Hydrochloride 75 mg. Tumors were pill increased by venlafaxine treatment in mice or rats. However, reduced fertility was observed in a study in which male and female rats were treated with O-desmethylvenlafaxine ODVthe pipl human metabolite of venlafaxine, prior to and during mating and gestation. This Medication Guide has been approved by the U. Skin and appendages - Infrequent: Nursing Patients should be advised to notify their physician l17 they are breast-feeding an infant. Caution is advised in administering venlafaxine tablets to patients with diseases or conditions that could affect hemodynamic responses or metabolism. In the six-month open-label study, children and adolescents had height increases that were less than expected based on data from age- and sex-matched peers. Age and Gender A pharmacokinetic pill of venlafaxine-treated patients from pilll studies involving both b. Metformin Hydrochloride Extended Release Imprint: Patients should be piill for these symptoms when discontinuing treatment with venlafaxine tablets. Venlafaxine tablets should also not be started in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue. Lung disease and pneumonia: Maintenance Treatment It is generally agreed that acute episodes of major depressive disorder require several months or longer of sustained pharmacological therapy beyond response to the acute episode. There may be circumstances when it is necessary to initiate pilp with a MAOI such as linezolid or intravenous methylene blue in a patient taking venlafaxine tablets. Screening Patients for Bipolar Disorder A major l178 episode may be the initial presentation of l178 disorder.

Nevertheless, sustained increases of this magnitude could have adverse consequences. Adaptation l178 Certain Adverse Events Over a 6-week period, there was evidence of l1178 to some l718 events with pi,l therapy eg, dizziness and nauseabut less pill other effects eg, abnormal ejaculation and dry mouth. Prescriptions for venlafaxine tablets should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose. Therefore, the potential exists for a drug interaction between drugs that inhibit Pill metabolism and venlafaxine. The safety and efficacy of venlafaxine therapy in combination with weight loss agents, including phentermine, have not been established. As with all antidepressants, venlafaxine tablets should be used cautiously in patients with a history of mania. None of the patients pilll venlafaxine hydrochloride extended release capsules discontinued for anorexia or weight loss. Based l178 the mechanism of action of SNRIs and SSRIs, including venlafaxine hydrochloride, and the potential for serotonin syndrome, caution is advised when venlafaxine l178 coadministered with other drugs that may affect the serotonergic neurotransmitter systems, pill as triptans, lithium, fentanyl, tramadol, amphetamines, or St. Ask if you are not sure. The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder OCDor other psychiatric disorders included a total of 24 short-term trials l17 9 antidepressant drugs in over patients. Pay particular attention to such changes when venlafaxine tablets is started or when the dose is changed. Venlafaxine and ODV exhibited linear kinetics over the dose range of 75 to mg total dose per day administered on pill q8h schedule. Such monitoring should include daily observation by families and caregivers, l178 pill. Pharmacokinetics Venlafaxine is well absorbed and extensively metabolized in the liver. A large degree of intersubject variability was noted. Such symptoms should be reported to the patient's prescriber or health professional, especially if they are severe, abrupt in onset, or were not part of the patient's presenting symptoms. Such patients should undergo a prompt medical evaluation, and discontinuation l178 venlafaxine therapy should be considered. Common possible side effects in people who take l178 tablets include: Venlafaxine tablets is pipl prescription medicine used to treat depression. Pill risk differences drug vs placebohowever, were relatively stable within age strata and across indications. Depression pill other p178 mental illnesses are the most important causes of suicidal thoughts or actions. Do not drink alcohol while using venlafaxine tablets.

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The patient should be monitored for symptoms of serotonin syndrome for l178 plll or until 24 hours after the last dose of linezolid or intravenous methylene blue, whichever comes first. No specific antidotes for venlafaxine are known. There was considerable variation in risk of suicidality among drugs, but a tendency toward an increase in the younger ppill for almost all drugs pilo. Food has no significant effect on the absorption of venlafaxine or on the formation of ODV. Drug-Laboratory Test Interactions False-positive urine pill screening tests for phencyclidine PCP and amphetamine have been reported in patients taking venlafaxine. Families and caregivers should ,178 advised of the need for close observation and communication with the prescriber. Prescription only Drug Pill Venlafaxine was not found to have any significant CNS stimulant activity in rodents. You should discuss all treatment choices with your healthcare provider. Caution should be exercised with co-administration of venlafaxine and metoprolol. Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, l178 pill, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms. Pi,l on the mechanism of action of SNRIs and SSRIs, including venlafaxine hydrochloride, and the l178 for serotonin syndrome, caution is advised when venlafaxine is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, amphetamines, or Ppill. It is important to talk with your healthcare provider about the risks of plil depression and also the risks of not treating it. NDCbottle of tablets. Such patients should undergo a prompt medical evaluation, and discontinuation of venlafaxine therapy should be considered. Case reports and epidemiological studies case-control and cohort design have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding. In vitro studies indicate that venlafaxine is a relatively weak inhibitor of CYP2D6. However, venlafaxine coadministration did l718 significantly alter the pharmacokinetic profile of the total active moiety risperidone plus 9-hydroxyrisperidone. Patients should be monitored for these symptoms when discontinuing treatment. How to identify a pill using the Pill Identifier? Your healthcare provider or pharmacist can tell you if it is safe to take venlafaxine tablets with l178 other medicines. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anti-coagulants may add to this risk.

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Inactive ingredients consist of cellulose, iron oxide red, iron oxide yellow,lactose monohydrate, magnesium stearate and crospovidone. Call your healthcare provider right away if you have any of the following symptoms, or call if an emergency, especially if they are new, worse, or worry you: Do not start or stop any medicine while taking venlafaxine tablets without talking to your healthcare provider first. The frequencies presented, therefore, represent the proportion of the patients exposed to multiple doses of either formulation of venlafaxine who experienced an event of the type cited on at least one occasion while receiving venlafaxine. Plasma levels of the O-desmethyl metabolite were lower in rats than in patients receiving the maximum recommended dose. Venlafaxine tablets is a prescription medicine used to treat depression. We comply with the HONcode standard for trustworthy health information - verify here. Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including venlafaxine tablets, alone but particularly with concomitant use of other serotonergic drugs including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. The most commonly reported events in over dosage include tachycardia, changes in level of consciousness ranging from somnolence to coma , mydriasis, seizures, and vomiting. The physician should consider contacting a poison control center for additional information on the treatment of any overdose. Patients should be monitored for these symptoms when discontinuing treatment. Musculoskeletal system - Infrequent: However, greater sensitivity of some older individuals cannot be ruled out. As with all antidepressants, venlafaxine tablets should be used cautiously in patients with a history of mania. O-desmethyl venlafaxine ODV is the only major active metabolite. Subscribe to receive email notifications whenever new articles are published. There were suicides in the adult trials, but the number was not sufficient to reach any conclusion about drug effect on suicide. Cases of elevated blood pressure requiring immediate treatment have been reported in post marketing experience. Available for Android and iOS devices. During the eight-week placebo-controlled GAD studies, venlafaxine hydrochloride extended release capsules-treated patients ages grew an average of 0. Read the Medication Guide that comes with venlafaxine tablets before you start taking it and each time you get a refill.

Available for Android and iOS devices. The clinical significance of this finding is unknown. Concomitant Medication Patients should be advised to inform their physicians if they are taking, or plan to take, any prescription or over-the-counter drugs, including herbal preparations and nutritional supplements, since there is a potential for interactions. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anti-coagulants may add to this risk. Serum Cholesterol Elevation Clinically relevant increases in serum cholesterol were recorded in 5. Pooled analyses of short-term placebo-controlled trials of antidepressant drugs SSRIs and others showed that these drugs increase the risk of suicidal thinking and behavior suicidality in children, adolescents, and young adults ages with major depressive disorder MDD and other psychiatric disorders. Search Results Search Again Results 1 - 7 of 7 for "l". In vitro and in vivo studies indicate that venlafaxine is metabolized to its active metabolite, ODV, by CYP2D6, the isoenzyme that is responsible for the genetic polymorphism seen in the metabolism of many antidepressants. Screening Patients for Bipolar Disorder A major depressive episode may be the initial presentation of bipolar disorder. In vitro studies indicate that venlafaxine is likely metabolized to a minor, less active metabolite, N-desmethylvenlafaxine, by CYP3A4. These are not all the possible side effects of venlafaxine tablets. Such monitoring should include daily observation by families and caregivers. Watch for these changes and call your healthcare provider right away if you notice: Read the Medication Guide that comes with venlafaxine tablets before you start taking it and each time you get a refill. Anxiety and Insomnia Treatment-emergent anxiety, nervousness, and insomnia were more commonly reported for venlafaxine-treated patients compared to placebo-treated patients in a pooled analysis of short-term, double-blind, placebo-controlled depression studies:. During marketing of venlafaxine tablets, other SNRIs Serotonin and Norepinephrine Reuptake Inhibitors , and SSRIs Selective Serotonin Reuptake Inhibitors , there have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly when abrupt, including the following: Nevertheless, sustained increases of this magnitude could have adverse consequences. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, venlafaxine tablets should be stopped promptly, and linezolid or intravenous methylene blue can be administered. Mild sinus tachycardia was reported in 2 of the other patients. All 14 patients recovered without sequelae. These findings have been confirmed in a clinical drug interaction study comparing the effect of venlafaxine to that of fluoxetine on the CYP2D6-mediated metabolism of dextromethorphan to dextrorphan. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed pill may be considered. Concomitant L178 Patients should be advised to inform their physicians if they are pill, or plan to take, any prescription or over-the-counter drugs, including herbal preparations and nutritional supplements, since there is a potential for interactions, l178 pill. A l178 reduction in the dose rather than abrupt cessation is recommended whenever possible. Decreased appetite has been observed in pediatric patients receiving venlafaxine hydrochloride extended release capsules. Postmarketing Reports Voluntary reports of other adverse events temporally associated with the use of venlafaxine that have been received since market introduction and that may have no causal relationship with the use of venlafaxine include the following:

Search for the imprint first, then refine by color and shape if you have too many results. Cablivi Cablivi caplacizumab-yhdp is a von Willebrand factor vWF -directed antibody Read the Medication Guide that comes with venlafaxine tablets before you start taking it and each time you get a refill. However, discontinuation for weight loss associated with venlafaxine was uncommon 0. If you take venlafaxine tablets, you should not take any other medicines that contain venlafaxine including: In managing overdosage, consider the possibility of multiple drug involvement. The frequencies presented, therefore, represent the proportion of the patients exposed to multiple doses of either formulation of venlafaxine who experienced an event of the type cited on at least one occasion while receiving venlafaxine. Protein-binding-induced drug interactions with venlafaxine are not expected. Subscribe to receive email notifications whenever new articles are published. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Plasma clearance, elimination half-life and steady-state volume of distribution were unaltered for both venlafaxine and ODV after multiple-dosing. Laboratory Tests There are no specific laboratory tests recommended. The clinical significance of this finding is unknown. Cimetidine Concomitant administration of cimetidine and venlafaxine in a steady-state study for both drugs resulted in inhibition of first-pass metabolism of venlafaxine in 18 healthy subjects. Prescription only Drug Class: Drugs that Interfere with Hemostasis e. Age and Gender A pharmacokinetic pill of venlafaxine-treated patients from two studies involving both b. It should be discontinued in any patient who develops seizures. Metabolic and nutritional - Frequent: Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Enter the imprint ;ill that appears on the pill e. O-desmethyl venlafaxine ODV is the only major active metabolite. Low l178 sodium levels in the blood. Hypersensitivity to venlafaxine hydrochloride or to any excipients in the formulation.